Ibutamoren: what the evidence actually shows
Ibutamoren is an orally active ghrelin receptor agonist that raises growth hormone and IGF-1 levels.
Also known as MK-677, MK677, ibutamoren mesylate.
Evidence and regulatory status
In registered human trials. Not approved for this use.
Not approved by the FDA for any indication. Prohibited in sport as a growth hormone secretagogue.
Half-life
A half-life figure for Ibutamoren has not been verified against a primary source for this page, so none is stated. The sources below are where a figure would come from.
What published trials used
- The 2008 Annals of Internal Medicine trial administered 25mg orally once daily for two years in healthy older adults.
Reported for reference only. What a trial administered under supervision is not a recommendation, and Gireta does not make one.
How much research exists
- PubMed records
- 138
- Tagged human
- 91
- Clinical trials
- 19
A PubMed search for Ibutamoren returns 138 records, of which 91 are tagged as human research and 19 are typed as a clinical trial.
Counted on . Counts drift, so the exact query is linked rather than described, and you can re-run it.
Common questions
- Is MK-677 FDA approved?
- No. Ibutamoren has been studied in registered human trials but has never been approved by the FDA for any indication.
- Is ibutamoren injected?
- It is taken by mouth rather than injected, which is unusual among growth hormone secretagogues and is the main practical difference people cite.
- How much human research exists on MK-677?
- There is more human data than for most compounds sold in the same channels: roughly ninety PubMed records tagged to human subjects and nineteen typed as clinical trials. The query is linked above.
Sources
- Nass 2008 · Annals of Internal Medicine, via PubMed, 2008
Related compounds
Growth hormone secretagogues
Prompt the pituitary to release growth hormone rather than supplying growth hormone directly.
- Tesamorelin Tesamorelin is a synthetic growth hormone-releasing factor analogue approved to reduce excess visceral abdominal fat in people with HIV-associated lipodystrophy.
- CJC-1295 CJC-1295 is a long-acting analogue of growth hormone-releasing hormone, modified to bind albumin and extend its duration of action.
- Ipamorelin Ipamorelin is a selective growth hormone secretagogue that acts at the ghrelin receptor.
Planning a schedule?
Gireta turns a compound and a cadence into a twelve-week timeline with the reconstitution maths worked out and a monthly cost.
Plan a Ibutamoren scheduleLast reviewed .